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Squamous cell carcinoma of the rectum: The treatment paradigm
Treatment of Anal Cancer, by Stage
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An abdomino perineal resection , formally known as abdominoperineal resection of the rectum and abdominoperineal excision of the rectum is a surgery for rectal cancer or anal cancer. The principal indication for AP resection is a rectal carcinoma situated in the distal lower one-third of the rectum. APRs involves removal of the anus , the rectum and part of the sigmoid colon along with the associated regional lymph nodes , through incisions made in the abdomen and perineum. The end of the remaining sigmoid colon is brought out permanently as an opening, called a colostomy , on the surface of the abdomen. This operation is one of the less commonly performed by general surgeons , although they are specifically trained to perform this operation.
Annals of Oncology , the journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology, provides rapid and efficient peer-review publications on innovative cancer treatments or translational work related to oncology and precision medicine. Main focuses of interest include: systemic anticancer therapy with specific interest on molecular targeted agents and new immune therapies , randomized trials including negatives ones , top-level guidelines, and new fields currently emerging as key components of personalized medicine, such as molecular pathology, bioinformatics, modern statistics, and biotechnologies. Radiotherapy, surgery and pediatrics manuscripts can be considered if they display a clear interaction with one of the fields above or are paradigm-shifting.